https://ogma.newcastle.edu.au/vital/access/ /manager/Index ${session.getAttribute("locale")} 5 Variant alleles of the CYP1B1 gene are associated with colorectal cancer susceptibility https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:10390 Wed 11 Apr 2018 12:49:05 AEST ]]> Multi-trait genome-wide association study of opioid addiction: OPRM1 and beyond https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:53302 0.9). We observed the strongest evidence to date for OPRM1: lead SNP rs9478500 (p = 2.56 × 10–9). Gene-based analyses identified novel genome-wide significant associations with PPP6C and FURIN. Variants within these loci appear to be pleiotropic for addiction and related traits.]]> Tue 21 Nov 2023 12:03:34 AEDT ]]> RAD51B in familial breast cancer https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:50033 T among the Finnish cancer patients and subsequently genotyped the mutation in additional breast cancer cases (n = 5259) and population controls (n = 3586) from Finland and Belarus. No significant association with breast cancer risk was seen in the meta-analysis of the Finnish datasets or in the large BCAC dataset. The association with previously identified risk variants rs999737, rs2588809, and rs1314913 was replicated among all breast cancer cases and also among familial cases in the BCAC dataset. The most significant association was observed for the haplotype carrying the risk-alleles of all the three SNPs both among all cases (odds ratio (OR): 1.15, 95% confidence interval (CI): 1.11-1.19, P = 8.88 x 10-16) and among familial cases (OR: 1.24, 95% CI: 1.16-1.32, P = 6.19 x 10-11), compared to the haplotype with the respective protective alleles. Our results suggest that loss-of-function mutations in RAD51B are rare, but common variation at the RAD51B region is significantly associated with familial breast cancer risk.]]> Thu 29 Jun 2023 13:56:37 AEST ]]> Systematic review and meta-analysis of the association between beta(2)-adrenoceptor polymorphisms and asthma: a HuGE review https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:550 Thu 25 Jul 2013 09:10:25 AEST ]]> Systematic review and meta-analysis of the association between beta(2)-adrenoceptor polymorphisms and asthma: A HuGE review https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:1555 Sat 24 Mar 2018 08:30:45 AEDT ]]> Schizophrenia risk from complex variation of complement component 4 https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:30050 Sat 24 Mar 2018 07:31:15 AEDT ]]>